To address the problems of local buckling of cold-formed thin-walled steel members and cracking of ceramsite lightweight concrete, while considering the aesthetic requirements for interior building layouts, a prefabricated cross-shaped column partially encased with cold-formed thin-walled steel and filled with lightweight concrete was proposed. To investigate the seismic performance of these special-shaped columns, four cross-shaped columns were designed and fabricated using different coarse aggregate replacement rates as a parameter, and the low cyclic reversed loading tests were carried out. Based on the experimental study, the finite element software ABAQUS was used to analyze the lightweight aggregate concrete strength, steel plate strength, steel plate thickness, and loading angle. The test results indicate that the hysteretic curves of the four specimens are symmetrical and full, exhibiting a shuttle shape. A compression-bending failure mode of the specimens was observed. As the coarse aggregate replacement rate increases from 0% to 30%, 70%, and 100%, the specimen weight decreases by 77 kg/m3, 176 kg/m3, and 252 kg/m3, respectively; the carbon emission reductions decrease by 19.18%, 38.11%, and 49.93%; the ultimate load-bearing capacity decreases by 1.0%, 4.7%, and 9.2%; the ductility coefficient increases by 1.4% at first, and then decreases by 3.8% and 4.2%; the energy dissipation reduces by 8.6%, 2.5%, and 6.7%. The use of fly ash ceramsite to replace ordinary stone as a concrete coarse aggregate has no significant effect on the seismic performance of the columns but shows great potential for carbon emission reduction compared to ordinary concrete. Increasing the strength of lightweight aggregate concrete does not significantly improve the load-bearing capacity, ductility, or energy dissipation performance of the specimens. When the steel plate strength increases from Q235 to Q355, the ultimate load-bearing capacity of the specimens increases by 45.1%. When the steel plate thickness increases from 4 mm to 5 mm and 6 mm, the ultimate load-bearing capacity of the specimens increases by 14.8% and 35.5%, respectively. The least favorable loading angle for the specimens is 45°.