四(N-咪唑甲基)二酚化合物的合成

Synthesis of Tetra-Imidazolylmethyl Bi-Phenol Compounds

摘要: 以联苯二酚、二酚A为原料,经羟甲基化和咪唑甲基化二步反应法合成四(N-咪唑甲基)二酚化合物.运用咪唑甲基化反应,0.02 mol化合物(2a,2b)与0.120 mol咪唑在5 mL的DMF中搅拌反应,温度控制在130~ 140℃,反应进行3~4 h,再升温至160~170℃,反应1 h,合成四(N-咪唑甲基)二酚化合物(3a,3b),产率3a 为57%,3b为59.3%.所得的目标化合物被MS,1HNMR, IR和元素分析证实.
- 咪唑 /
- 合成 /
- 四(N-咪唑甲基)二酚 /
- 四(N-咪唑甲基)联苯二酚
Abstract: Tetra-imidazolylmethyl bi-phenol compounds (3a,3b) are efficiently synthesized and structurally confirmed. 4, 4 -dihydroxydiphenylpropane and 4,4 -biphenol are respectively treated with paraformladehyde to give tetra-hydroxyl derivative (2a,2b). Treatment of (2a,2b) with imidazole at 130 to 140℃and 160 to 170℃in DMF gives the corresponding tetra-imidazolylmethyl bi-phenol (3a,3b). The chemical yields of 3aand 3bare 57% and 59.3% respectively. Tetra- imidazolmethyl bi-phenol compounds obtained have been confirmed by MS,1HNMR, IR measurements and elemental analyses.
- imidazole /
- synthesis /
- tetra-imidazolylmethyl compound /
- tetra-imidazolylmethyl bi- phenol

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