Abstract: China devoted major efforts to develop high-speed railways. In order to deal with the impacts on the regional highway system from the project of high-speed railways, methods for forecasting the indexes of GDP, population, highway passenger volume and highway freight volume were put forward according to the characteristics of high-speed rail transportation by analyzing the law of historical data. Based on the forecast results of the four indexes, a method for calculating the quantity of highway hubs was designed using the node importance method, and a method for classifying the highway hubs was designed using the clustering analysis method. The methods above were tested in the example of Changchun-Jilin high-speed railway construction project. The results show that the optimal number of highway hubs in Jilin province should be 14 to 18 , classified into 6 national highway hubs, 2 provincial level one highway hubs and 9 provincial level two highway hubs.