Abstract: In order to research the seismic behavior of core-tie-column, non-linear dynamic time-history responses of three types of two-story masonry structures with the same architectural layouts were analyzed. They are a masonry structure without restriction and two masonry structures with four core-tie-columns (CTC) or four cast-in-place tie-columns (CPTC). Their periods, vibration modes, acceleration responses, deformations and plastic strains in walls were contrasted and analyzed. The research results show that the period of a masonry structure with CTC or CPTC is shorter than that of a masonry structure without restriction, and the vibration modes of all these masonry structures are almost identical. Under a seismic intensity of 8 degrees, the maximum acceleration responses of the masonry structure with CTC or CPTC are much greater than that of the structure without restriction, and compared with the structure without restriction, the masonry structure with CTC or CPTC has significantly small story-drifts and plastic strains in the walls. The seismic behavior of the masonry structure with CTC is improved and close to that of the masonry structure with CPTC.