Abstract: The dissolution of carbonate rocks is simulated by experiments. The thermodynamic equations are derived to study the dissolution quantitatively under 3 temperature and pressure conditions, namely, 348.15 K and 20 MPa, 373.15 K and 25 MPa, and 403.15 K and 30 MPa. Dolomite is much easier to dissolve and lead to deposition of oil and natural gas than the limestone is. The engineering geologic significance of the study is that the geological conditions should be considered for the location of a newcity, railway, tunnel, and so on, to avoid the risk of geological disasters.