邻氯代环己酮肟及其类似物的合成

Synthesis ofo-Chloro-Cyclohexanone Oxime and ItsAnalog

摘要: 分别以环己酮、环己烯、2-甲基-2-丁烯为初始反应物合成邻氯代酮肟及其类似物·结果表明,用结构对应的相应酮,经先氯代后成肟的合成路线,反应温度为0~5℃时,可得到接近理论产率的邻氯代环己酮肟.对 α-氯-α-甲基丁酮肟,选择结构对应的烯烃与亚硝酸酯加成,再使加成产物在乙醇溶剂中重排,可得到高产率.
- 邻氯代环己酮肟 /
- α-氯-α-甲基丁酮肟 /
- 类似物 /
- 合成
Abstract: o-Chloro-cyclohexanone oxime and its analog were synthesized with cyclohexanone, cyclohexene and 2-methyl-2-butene. The results show that almost theoretical yield foro-Chloro- cyclohexanone oxime is obtainable with chloro-oximation reaction from hexanone, chlorine and hydroxylamine hydrochloride at0~5℃, and thathigh yield forα-chloro-α-methylbutanone oxime is also securablewith the addition reaction from alkene and nitrous acid ester followed by rearranging the resultant in ethanol solven
- o-chloro-cyclohexanone oxime /
- α-chloro-α-methylbutanone oxime /
- analog /
- synthesis

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