Abstract: High rising buildings with a large bay supermarket on their two lowest stories and dwelling houses on the other stories were taken as the discussed object. Based on the relative national design codes and their engineering conditions, seismic responses of 72 high rising buildings of RC frame structures with special-shaped columns and a girder-transfer story were calculated respectively using the modal analysis method and the elastic time-history method, and in the calculation, different combinations of fortification intensities 7 and 8 and site soil typesⅠtoⅣwere considered. From the calculated result, the changes in their story drift, storyshear andmomenton structural bottomwere analyzed underthe condition of frequently occurred earthquakes, and some conclusions helpful for the design of high rising buildings were obtained.