Abstract: By combining quantitative calculation and qualitative analysis, the transport operation mode and its feasibility, and the off-line train running scheme of Wuhan-Guangzhou passenger special line were investigated. The research shows that a multi-speed transport mode should be adopted in the passenger special line. In this mode, off-line and in-line trains share the same line, and the combined traction way of a motor train unit and an ordinary locomotive is used for off-line trains.