Microsphere Agglomeration Technique for Drug Release from Porous-Coated Ti

WANG Dongwei; XIAO Dongqin; DUAN Ke; LU Xiong; FENG Bo; WENG Jie

doi:10.3969/j.issn.0258-2724.2015.04.020

Volume 28 Issue 4

Jul. 2015

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Journal of Southwest Jiaotong University > 2015 > 28(4): 703-709.

WANG Dongwei, XIAO Dongqin, DUAN Ke, LU Xiong, FENG Bo, WENG Jie. Microsphere Agglomeration Technique for Drug Release from Porous-Coated Ti[J]. Journal of Southwest Jiaotong University, 2015, 28(4): 703-709. doi: 10.3969/j.issn.0258-2724.2015.04.020

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WANG Dongwei, XIAO Dongqin, DUAN Ke, LU Xiong, FENG Bo, WENG Jie. Microsphere Agglomeration Technique for Drug Release from Porous-Coated Ti[J]. Journal of Southwest Jiaotong University, 2015, 28(4): 703-709. doi: 10.3969/j.issn.0258-2724.2015.04.020

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Microsphere Agglomeration Technique for Drug Release from Porous-Coated Ti

doi: 10.3969/j.issn.0258-2724.2015.04.020

WANG Dongwei^1,2,3,
XIAO Dongqin^1,2,3,
DUAN Ke^{1,2
,
,},
LU Xiong^1,2,
FENG Bo^1,2,
WENG Jie^1,2

Received Date: 24 Oct 2013
Publish Date: 25 Aug 2015

Abstract

Abstract

A microsphere agglomeration technique incorporating gentamicin in porous-coated Ti was used to overcome technical disadvantages associated with available drug-release techniques for bone implants. Chitosan microspheres containing various concentrations of gentamicin were prepared by a water-in-oil emulsion method and lyophilized to dry powders. The powders were then spread on porous-coated Ti, and wetted with water to promote their agglomeration after they enter into the pores by gently tapping the samples. Microscopical analyses revealed that, the microspheres formed submilllimeter-sized agglomerates and entrapped in the pores. After immersion in shaking water bath (100 r/min, 37 ℃) for 7 d, 80%-83% of the agglomerates were retained in the coating, suggesting a reasonable entrapment stability. The microsphere-porous Ti complexes showed a rapid drug release in 24 h followed by a prolonged slow release. After coculture with Staphylococcus aureus for 48 h, the porous Ti carrying gentamicin-loaded microspheres produced clear inhibition zones, confirming its In vitro antibacterial activity.
- porous Ti,
- microsphere,
- agglomeration,
- bone implant,
- drug release

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Microsphere Agglomeration Technique for Drug Release from Porous-Coated Ti

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