• ISSN 0258-2724
  • CN 51-1277/U
  • EI Compendex
  • Scopus
  • Indexed by Core Journals of China, Chinese S&T Journal Citation Reports
  • Chinese S&T Journal Citation Reports
  • Chinese Science Citation Database
Volume 25 Issue 1
Mar.  2012
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Article Contents
LIU Yanqiu, HUANG Nan, ZOU Yuanwen, HUANG Xuejin, LI Jinchuan, FAN Yubo. Quantitative Analysis of Parameters of Vascular Bioreactor[J]. Journal of Southwest Jiaotong University, 2012, 25(1): 139-143,150. doi: 10.3969/j.issn.0258-2724.2012.021.01.023
Citation: LIU Yanqiu, HUANG Nan, ZOU Yuanwen, HUANG Xuejin, LI Jinchuan, FAN Yubo. Quantitative Analysis of Parameters of Vascular Bioreactor[J]. Journal of Southwest Jiaotong University, 2012, 25(1): 139-143,150. doi: 10.3969/j.issn.0258-2724.2012.021.01.023

Quantitative Analysis of Parameters of Vascular Bioreactor

doi: 10.3969/j.issn.0258-2724.2012.021.01.023
  • Received Date: 28 Oct 2010
  • Publish Date: 25 Feb 2012
  • A vascular bioreactor was designed and constructed by Beihang University and Sichuan University for Southwest Jiaotong University for simulating in vivo environments. The performance indicators of the bioreactor including shearing stress, the state of laminar flow, and pulse pressure were analyzed quantitatively through theoretical derivation of hydromechanics and orthogonal experiment range analysis. The results show that for blood vessels of different diameters, the bioreactor could provide shearing stress ranging from 0.08 to 70.51 Pa. In order to maintain a laminar flow condition of the perfusate, the maximum flow rate in the tubes of five kinds of diameters should not exceed 4.36 cm3/s when the inlet tube length of the culture chamber was 18 cm, and the viscosity coefficient and fluid density of the perfusate were fixed. The operating distance of the pulsation generator had a bigger effect on the difference between systolic and diastolic blood pressures than the flow and frequency, while the effect of pressure was the smallest.

     

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